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Novel imidazopyridazine compounds and their use
专利权人:
Hutchison Medipharma Limited
发明人:
SU, Wei-Guo,DAI, Guangxiu,ZHANG, Weihan,DENG, Wei
申请号:
ES15843649
公开号:
ES2765510T3
申请日:
2015.09.23
申请国别(地区):
ES
年份:
2020
代理人:
摘要:
A compound of formula (I): ** (See formula) ** and / or a pharmaceutically acceptable salt thereof, and / or its solvates, racemic mixture, enantiomers, diastereomers, and tautomers, in which Ar is aryl, said aryl is a carbocyclic hydrocarbon radical of a monocyclic ring or fused rings containing 6-12 ring carbon atoms, in which at least one ring is aromatic and none of the other rings is heteroaryl; or heteroaryl, said heteroaryl is a monocyclic aromatic hydrocarbon radical having 5, 6 or 7 ring atoms, and containing 1 or 2 heteroatoms independently chosen from N, O, and S in the ring, the remaining ring atoms being carbon; or a bicyclic aromatic hydrocarbon radical having 9 or 10 ring atoms, and containing 1, 2, 3 or 4 heteroatoms independently chosen from N, O, and S in the rings, the remaining ring atoms being carbon, in which at least one of the rings is aromatic; when the total number of S and O atoms in the heteroaryl group exceeds 1, those heteroatoms are not adjacent to each other, and said heteroaryl group also includes those in which the N heteroatom appears as Noxide; each of said aryl and heteroaryl is optionally substituted with one or more groups selected from deuterium, halo, -CN, -OH, -SH, C1-6 alkyl, C1-6 haloalkyl, - (C1-6 alkyl) OH , and -S (O) 2 (C1-6 alkyl); W is chosen from heteroaryl and -N (R3) heteroaryl, wherein said heteroaryl is a nitrogen-containing monocyclic aromatic hydrocarbon radical having 5, 6, or 7 ring atoms, and containing 1 or 2 heteroatoms, wherein the heteroatom or heteroatoms are nitrogen atoms, the remaining ring atoms being carbon; or a nitrogen-containing bicyclic aromatic hydrocarbon radical having 9 or 10 ring atoms, and containing 1, 2, 3, or 4 heteroatoms, wherein the heteroatom or heteroatoms are nitrogen atoms, the remaining ring atoms being carbon, in the that at least one of the rings is aromatic; and said heteroaryl group also includes those in which the N heteroatom appears as N-oxide, and said heteroaryl is o
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