James W. Yockman,Jonathan Brumbach,Lane V. Christensen,Sung Wan Kim
申请号：
US12266980
公开号：
US08829109B2
申请日:
2008.11.07
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Improved poly(amido ethylenimine) copolymers for gene delivery are disclosed. One illustrative embodiment includes polyethylene glycol (PEG) covalently bonded to a branched poly(triethyenetetramine/cystamine bisacrylamide) copolymer (poly(TETA/CBA)). The polyethylene glycol can be linear or branched. Another illustrative embodiment includes an RGD peptide covalently bonded to the poly(TETA/CBA)-PEG conjugate. Still another illustrative embodiment includes a method of using these compositions for transfecting a cell with a nucleic acid.
