Yockman, James William,Brumbach, Jonathan H.,Kim, Sung Wan
申请号：
AU2011227264
公开号：
AU2011227264A1
申请日:
2011.03.16
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
Polyplex formulations were prepared using p(TETA/CBA), its PEGylated analog, p(TETA/CBA)-g-PEG2k, and mixtures of the two species at 10/90 and 50/50 wt %, respectively. Increasing PEG wt% inhibited polyplex formation. This work demonstrates the feasibility of preparing homogenous polyplexes by altering the PEG wt% using a mixture of p(TETA/CBA) and p(TETA/CBA)-g-PEG2k products. Further, a single-step method of making p(TETA/CBA)-g-PEG2k is disclosed.
