WHITE, Brian H.,BILODEAU, Mark T.,MOREAU, Benoit,SHINDE, Rajesh R.,LIM SOO, Patrick,SWERYDA-KRAWIEC, Beata,BAZINET, Patrick Rosaire,ALARGOVA, Rossitza G.,DUNBAR, Craig A.
申请号：
PH12017502392
公开号：
PH12017502392A1
申请日:
2017.12.21
申请国别(地区):
PH
年份:
2018
代理人:
摘要：
Nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as maytansinoid attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker have been designed. Such nanoparticles and microparticles can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided.
