WHITE, BRIAN H.,BILODEAU, MARK T.,MOREAU, BENOIT,SHINDE, RAJESH R.,LIM SOO, PATRICK,SWERYDA-KRAWIEC, BEATA,BAZINET, PATRICK ROSAIRE,ALARGOVA, ROSSITZA G.,DUNBAR, CRAIG A.
申请号：
CA2988591
公开号：
CA2988591A1
申请日:
2016.06.27
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as maytansinoid attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker have been designed. Such nanoparticles and microparticles can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided.
