COMPOSITION DE COMPOSÉ À PETITE MOLÉCULE QUI INDUIT EFFICACEMENT LA DIFFÉRENCIATION DE CELLULES SOUCHES MULTIPOTENTES HUMAINES EN CELLULES MYOCARDIQUES
Chinese Academy Of Sciences;Shanghai Institutes For Biological Sciences
发明人:
申请号：
EP17740994.3
公开号：
EP3406248A4
申请日:
2017.01.12
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
Disclosed is a small molecule compound composition that efficiently induces the differentiation of human pluripotent stem cells into myocardial cells. In particular, provided in the present invention is a small molecule compound composition. The small molecule compound composition comprises the following components: (i) an mTOR signaling pathway inhibitor； (ii) a Wnt pathway promoter； and (iii) optionally, a pharmaceutically acceptable carrier. The small molecule compound composition in the present invention can efficiently induce the differentiation of human pluripotent stem cells into myocardial cells. The preliminarily screened cardiomyocyte differentiation rate reaches up to 86%, and the optimized cardiomyocyte differentiation rate reaches up to 98.3%.
