The invention relates to an arrangement and method for the in-vitro and in-vivo treatment of bronchial tumors.The aim of the invention to provide an arrangement and a method for operating said arrangement for the in-vitro and in-vivo treatment of bronchial tumors, with said arrangement making the lungs receptive to ultrasound in order to allow the mechanical ultrasound waves to be guided through the healthy lung tissue to the tumor tissue in an optimized manner for the use of FUS therapy, is achieved in that the arrangement comprises a ventilation and respirator system (1) for a lung part to be provided with a gas for respiratory purposes (33), a device for the controlled ventilation and flooding (2) of a lung part to be flooded (34) with a liquid, a therapy system (4), and a central control unit (5), wherein the therapy system (4) consists of at least one therapeutic ultrasonic transducer (40), an imaging-monitoring system (42), and a temperature-monitoring system (41), and the central control unit (5) is connected to the therapeutic ultrasonic transducer (40), the respirator system (1), the device for the controlled ventilation and flooding processes (2), the imaging-monitoring system (42), and the temperature-monitoring system (41) for data-transmission purposes, the respirator system (1) and the device for the controlled ventilation and flooding (2) processes have a gas- and liquid-conducting connection to a lung tube (3), the lung tube (3) can be inserted into a lung containing a tumor (35) in an intratracheal manner, and therapeutic ultrasound doses can be administered by the ultrasonic transducer (40).
