Method for the synthesis of clofarabine

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专利权人:

Synbias Pharma AG

发明人:

Zabudkin Alexander,Matvienko Victor,Matviienko Iaroslav,Sypchenko Volodymyr

申请号：

NZ72521915

公开号：

NZ725219A

申请日:

2015.04.22

申请国别(地区):

NZ

年份:

2017

代理人:

摘要：

Method for the production of the anticancer nucleoside clofarabine in high yield, the method comprising the preparation of 2- chloroadenosine by enzymatic transglycosylation between 2- chloroadenine and nucleosides, benzoylation, isomerization, sulfonate ester formation, fluorination, and deprotection.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/