WEI BINQING,CRAWFORD JAMES JOHN,ORTWINE DANIEL FRED,YOUNG WENDY B.
申请号：
NZ62402112
公开号：
NZ624021A
申请日:
2012.11.02
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed are heteroaryl pyridone and aza-pyridone compounds of formula I useful for inhibiting Bruton&rsquo；s Tyrosine (Btk) kinase, wherein the substituents are as defined in the specification. Also disclosed are methods of using compounds of formula I for in vitro, in situ, and in vivo diagnosis, and treatment of disorders associated with Btk kinase including inflammation, immune disorders, and cancer. An example of a compound of formula (I) is: 2-(4-(hydroxymethyl)-5-(1-methyl-5-(5-(4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-ylamino)-6-oxo-1,6-dihydropyridin-3-yl)pyridin-3-yl)-3,4,6,7,8,9-hexahydropyrazino[1,2-a]indol-1(2H)-one
