Methods and systems for controlling an insulin pump in response to glucose measurements are responsive to a base insulin delivery profile and a temporary insulin delivery profile. These can be used, e.g., to control blood glucose level of a subject using a continuous glucose monitor and an insulin infusion pump. During a selected time range, an insulin amount for the pump to supply is determined using the temporary insulin delivery profile. Outside that time range, the insulin amount is determined using the base insulin delivery profile. The temporary insulin delivery profile can specify an exact amount to be supplied (a “hard” profile), a nominal amount to be supplied if doing so does not drive glucose out of a desired zone (“soft”), or a soft profile with a minimum amount of insulin to be delivered (“semi-soft”).本發明揭示用於回應於葡萄糖測量值以控制一胰島素泵之方法及系統，該等方法及系統係回應於一基本胰島素輸送曲線及一暫時胰島素輸送曲線。可使用此等曲線以例如使用一持續葡萄糖監測器及一胰島素輸液泵來控制一對象之血液葡萄糖位準。於一選定時間範圍期間，使用該暫時胰島素輸送曲線來決定該泵供應之胰島素量。在彼時間範圍外，使用該基本胰島素輸送曲線來決定該胰島素量。該暫時胰島素輸送曲線可指定：要供應之精確量(「硬式」曲線)；要供應之標稱量，若如此做不會使葡萄糖超過所要區帶(「軟式」)；或一軟式曲線，其具有要輸送的最少胰島素量(「半軟式」)。
