Rama Rao Amara,June R. Scott,Bernard Quigley,Venkateswarlu Chamcha
申请号:
US14422490
公开号:
US20150231228A1
申请日:
2013.09.06
申请国别(地区):
US
年份:
2015
代理人:
摘要:
This disclosure relates to recombinant bacteria, e.g. L. lactis, expressing heterologous pili containing human immunodeficiency virus (HIV) antigens. In certain embodiments, the recombinant bacteria are administered in combination with other HIV antigens, nucleic acids encoding HIV antigens, recombinant virus encoding HIV antigens, anti-viral agents and/or adjuvants in an effective amount to elicit a mucosal immune response against HIV.