Helene Rey,Olaf Mundszinger,Isabelle Golfier,Silvia Jakob,Oliver Rusch
申请号：
US14828028
公开号：
US20160256451A1
申请日:
2015.08.17
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to a pharmaceutical composition comprising a μ-receptor antagonist as an active substance, wherein the antagonist is prepared in an extended release formulation. The composition is intended for the treatment of patients with opioid-induced constipation, wherein the dosage of the μ-receptor agonist is independent of the opioid dosage. The preferred dosage of the μ-receptor antagonist of the composition is equivalent to a daily dosage of 20-70 mg naloxone.
