Christel Jeanne Marie MENET;Alastair James HODGES;Huw David VATER
发明人:
Christel Jeanne Marie MENET,Alastair James HODGES,Huw David VATER
申请号：
US15694454
公开号：
US20180078547A1
申请日:
2017.09.01
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A pyrazolopyridine compound according to Formula I, able to inhibit JAK is disclosed, as well as pharmaceutically acceptable salts, a solvate thereof, solvates of the pharmaceutically acceptable salts and biologically active metabolites thereof. The compound may be prepared as a pharmaceutical composition, and may be used for the treatment or prophylaxis of a variety of conditions in mammals including humans, and particularly, such conditions as may be associated with aberrant JAK activity, including by way of non-limiting example, allergy, inflammatory conditions, autoimmune diseases, proliferative diseases, transplant rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6.
