CARY, STEPHEN P. L.,KRTOLICA, ANA,LE MOAN, NATACHA,WINGER, JONATHAN A.,LEONG, KEVIN G.
申请号:
CA2979974
公开号:
CA2979974A1
申请日:
2016.03.17
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
The invention provides methods to modulate hypoxia-mediated tumor immunity by administration of an O2 carrier polypeptide (e.g., an H-NOX protein). The methods of the invention target both hypoxia inducible factor 1 alpha (HIF-1a) pathways and non-HIF-1a pathways of tumor immunity. Such methods are useful in the treatment of a wide variety of cancers and may be used alone or in combination with other anti-cancer therapies.