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Therapeutically active complexes
专利权人:
Hamlet Pharma AB
发明人:
Catharina Svanborg,Chin Shing Ho
申请号:
GB201810108
公开号:
GB2574845A
申请日:
2018.06.20
申请国别(地区):
GB
年份:
2019
代理人:
摘要:
A peptide which comprises a N-terminal fragment of SEQ ID NO 1 of up to 19 amino acids in length. This peptide could for example have the amino acid sequence of SEQ ID NO 2 (Sar1a1) or SEQ ID NO 6 (Sar1a2). Both SEQ ID NO 2 and SEQ ID NO 6 are demonstrated to kill human lung carcinoma cells (A549, ATCC) in cell death assays. Also disclosed is a biologically active complex comprising a peptide which comprises a truncated form of SEQ ID NO 1 of up to 19 amino acids in length in combination with oleic acid or a salt thereof. The complexes may be uses in therapy or the treatment of cancer. The oleate salt may be water soluble and may be an alkali metal salt such as sodium oleate or potassium oleate. MAGWDIFGWFRDVLASLGLWNKH (SEQ ID NO 1) MAGWDIFGWFRDVLA (SEQ ID NO 2) WFRDVLASLGLWNKH (SEQ ID NO 6)
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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