An imaging system selects a medical imaging protocol using a repository of information associating multiple ranges of contrast agent peak time with corresponding different imaging protocols. An imaging protocol comprises a method for acquiring images using an imaging system and using data identifying at least one of (a) an imaging rate within an imaging scan cycle and (b) an interval between imaging scans. A contrast agent peak time comprises a time a contrast agent concentration substantially reaches a peak value in an anatomical region of interest of a patient relative to a time of start of contrast agent injection. A contrast agent peak time detector detects a contrast agent peak time. An imaging processor adaptively selects an imaging protocol from the imaging protocols in response to a comparison of a detected contrast agent peak time with at least one of the plurality of ranges.