Alyssa M. Morimoto;Richard Boismenu;Romeo Maciuca;Michael J. Townsend;William D. Kennedy;Jacqueline McBride;Jorn Drappa
发明人:
Alyssa M. Morimoto,Jacqueline McBride,Richard Boismenu,Romeo Maciuca,William D. Kennedy,Michael J. Townsend,Jorn Drappa
申请号：
US14113575
公开号：
US20140056889A1
申请日:
2012.04.26
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention provides methods and compositions for treating various autoimmune diseases (such as systemic lupus erythematousu) with an interferon inhibitor (such as an anti-intereron-alpha monoclonal antibody). More specifically, the invention provides a method of diagnosing, monitoring and adjusting the treatment of such a patient by way of an interferon signature metric (interferon response gene measurement value), a certain anti-dsDNA antibody titre or being ENA− (levels of extractable nuclear antigens lower than a healthy level). Furthermore, the invention provides articles of manufacture associated with such a diagnosis.
