The present invention provides a physiological sensing method and device thereof, two ends of the device provides with straps respectively, and the device places on the wrist of subject. At least two physiological sensors arrange along the strap to generate at least one original physiological signal to the controller, let the controller filter the two original signal to generate two reference energy values, and the controller multiplies the two original physiological signals by corresponding the two reference energy values to generate two reference estimation parameters, and then inputs the standard physiological value equation to produce a standard physiological value. The arrangement of the sensor of the invention can be matched with the wrists of various sizes, and at the same time, the special physiological signal estimation method can be used to improve the accuracy of measuring physiological signals.本發明為一種生理感測方法及其裝置，裝置的兩端分別設有綁帶，以設置在受測者手腕上，至少二生理感測器沿著綁帶排列設置以產生原始生理訊號至控制器，使控制器對原始訊號進行濾波後，轉換成二基準能量值，令控制器將二基準生理訊號及其對應產生的二基準能量值相乘，以產生二基準估測參數後輸入標準生理值方程式中，以產生一標準生理值。本發明感測器的排列方式可吻合各種尺寸的手腕，同時搭配特殊的生理訊號估測方法，可有效提升量測生理訊號的精準度。
