A method for controlling an optoacoustic imaging system includes the steps of analyzing sinogram data values to identify variations, storing information concerning the variations, generating first and second sinograms, and processing the sinograms to mitigate the effect of the variations. In the analyzing step, sinogram data values are analyzed to identify one or more variations that are related to performance of one or more of the discrete components of the optoacoustic imaging system. The identified variations are then stored. A first sinogram is generated by sampling transducer elements acoustically coupled with a surface of a volume for a predetermined period of time after delivery of a pulse of light having a first wavelength, the first sinogram containing one channel for each of the transducer elements. A second sinogram is generated by sampling the transducer elements acoustically coupled with the surface of the volume for the predetermined period of time after delivery of a pulse of light having a second wavelength, the second sinogram containing one channel for each of transducer elements. The first and second sinograms are processed using the stored information to mitigate the effect of the identified variations on the respective sinogram.Linvention concerne un procédé de commande dun système dimagerie optoacoustique comprenant les étapes consistant à analyser des valeurs de données de sinogramme afin didentifier des variations, stocker des informations concernant les variations, générer des premier et second sinogrammes, et traiter les sinogrammes afin datténuer leffet des variations. Dans létape danalyse, des valeurs de données de sinogramme sont analysées pour identifier au moins une variation qui est liée à la performance dau moins un des composants discrets du système dimagerie optoacoustique. Les variations identifiées sont ensuite stockées. Un premier sinogramme est généré par échantillonnage des éléments transducteurs couplés de manière acoustique
