Meike De Wit,Remondus Johannes Adriaan Fijneman,Cornelia Ramona Jimenez,Gerrit Albert Meijer
申请号：
US13262711
公开号：
US20120093734A1
申请日:
2010.03.31
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Protein-based methods and compositions for the diagnosis of colorectal adenocarcinoma are disclosed. A method for identifying cell-surface proteins, which are transmembrane proteins or proteins with a signal peptide and which are over-expressed in colorectal cancer (CRC) is disclosed. Biomarkers found with this method, diagnostic methods using them and contrast agents directed to them for use in magnetic resonance imaging (MRI) and/or magentic photon imaging (MPI) are disclosed. The methods and biomarkers allow for differentiating progressive (high-risk) CRC (adenocarcinomas) from non-progressive (low-risk) colorectal adenomas.
