Method for producing intermediates for the production of novel macrocycles that are inhibitors of the proteasomic degradation of p27, such as argyrin and derivatives thereof, and uses of said macrocycles
Ulrike Eggert;Markus Kalesse;Nisar Malek;Andreas Rentsch;Tobias Brodmann;Anna-Katharina Girbig;Leila Bülow;Ronald Frank
发明人:
Markus Kalesse,Nisar Malek,Ronald Frank,Tobias Brodmann,Leila Bülow,Andreas Rentsch,Anna-Katharina Girbig,Ulrike Eggert
申请号：
US13000516
公开号：
US09458200B2
申请日:
2009.06.23
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to the use of particular macrocycles that are inhibitors of the proteasomic degradation of p27, in particular argyrin and derivatives thereof, for a treatment in a variety of conditions, such as the induction of immunotolerance, autoimmune diseases, bacterial infections, and proliferative diseases, such as cancers.
