A medical vacuum sealing drainage device includes a porous foam soft cushion (1) drainage tubes (2) which are positioned in the porous foam soft cushion (1) with the tail ends extending outside the porous foam soft cushion (1) and elastic sealing rubber films (3) positioned outside the porous foam soft cushion (1).The elastic sealing rubber films (3) have sealing openings (3a) for tubes including the drainage tubes (2) to extend outside and the opening diameters of the sealing openings (3a) are less than the outer diameters of the corresponding tubes which extend outside. When the device is used for the drainage of orthopedics or perineum the elastic sealing rubber films (3) are respectively positioned around the position on which penetration needles (9a) or an anus inserting catheter (11) penetrate the device and the sealing openings (3a) are used to realize the sealing around the penetration needles (9a)
