CHEN, CHIN CHU,陈劲初,陳勁初,YEH, SHU HSING,叶淑幸,葉淑幸,LEE, LI YA,李丽雅,李麗雅,HSU, JUI HSIA,徐瑞霞,CHEN, YEN PO,陈彦博,陳彥博
申请号：
TW105134531
公开号：
TW201816116A
申请日:
2016.10.26
申请国别(地区):
TW
年份:
2018
代理人:
摘要：
The present invention provides a use of a Cordyceps cicadae active substance for preparing an oral composition for decreasing intraocular pressure. The Cordyceps cicadae active substance is prepared by the following steps of: (a) culturing Cordyceps cicadae mycelia on a plate medium at 15-35 DEG C for 5-14 days； (b) innoculating the cultured Cordyceps cicadae mycelia of step (a) into a flask and culturing at 15-35 DEG C, pH 2-8 for 3-10 days； (c) inoculating the cultured Cordyceps cicadae mycelia of step (b) into a fermentation tank and culturing at 15-35 DEG C, pH 2-8 for 3-10 days to form a Cordyceps cicadae mycelia fermentation liquid； (d) freezing and drying the Cordyceps cicadae mycelia fermentation liquid and then grinding it into powder to form a freeze-dried Cordyceps cicadae mycelia powder； and (e) extracting the freeze-dried Cordyceps cicadae mycelia powder with a solvent to form a Cordyceps cicadae mycelia extract containing the Cordyceps cicadae active substance.本發明提供一種蟬花活性物質用於製備降低眼壓之口服組合物的用途。此蟬花活性物質係經下列步驟製備：(a)取蟬花菌絲體於平板培養基上，於15-35℃培養5-14天；(b)將步驟(a)培養後之蟬花菌絲體接種至燒瓶內，於15-35℃、pH 2-8的條件培養3-10天；(c)將步驟(b)培養後之蟬花菌絲體接種至發酵槽內，於15-35℃、pH 2-8的條件培養3-10天，形成蟬花菌絲體發酵液；(d)將蟬花菌絲體發酵液冷凍乾燥後磨粉，形成蟬花菌絲體凍乾粉；及(e)將蟬花菌絲體凍乾粉以溶劑萃取，形成含有蟬花活性物質之蟬花菌絲體萃取液。
