HALEY, GREGORY J.,哈尔利,哈爾利,KUCERA, DAVID,古大卫,古大衛,RUEDEN, ERIK J.,卢伊登,盧伊登,WANG, TINGMIN,王廷曼,王廷曼,BLATTER, FRITZ,布拉特,布拉特,VIERTELHAUS, MARTIN,维尔特,維爾特
申请号：
TW096138583
公开号：
TWI415854B
申请日:
2007.10.16
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
The present disclosure relates to p-toluene sulfonic acid salt of 5-amino-3-(2’-O-acetyl-3’-deoxy-beta-D-ribofuranosyl)-3H-thiazolo[4,5-d]pyrimidin-2-one and to its use in treating conditions such as viral infections, tumors, and cancer.Also disclosed is a method of preparing the p-toluene sulfonic acid salt of 5-amino-3-(2’-O-acetyl-3’-deoxy-β-D-ribofuranosyl)-3H-thiazolo[4,5-d]pyrimidin-2-one and methods for producing furanose compounds which are useful intermediates in the preparation of pharmaceutical compounds such as p-toluene sulfonic acid salt of 5-amino-3-(2’-O-acetyl-3’-deoxy-β-D-ribofuranosyl)-3H-thiazolo[4,5-d]pyrimidin-2-one and the like.本揭示係關於5-胺基-3-(2’-O-乙醯基-3’-去氧-β-D-呋喃核糖基)-3H-噻唑并[4,5-d]嘧啶-2-酮之對甲苯磺酸鹽及其於治療諸如病毒感染、腫瘤及癌症病況之用途。亦揭示者為一種製備5-胺基-3-(2’-O-乙醯基-3’-去氧-β-D-呋喃核糖基)-3H-噻唑并[4,5-d]嘧啶-2-酮之對甲苯磺酸鹽之方法及生產呋喃糖化合物之方法,此呋喃糖化合物為於醫藥化合物諸如5-胺基-3-(2’-O-乙醯基-3’-去氧-β-D-呋喃核糖基)-3H-噻唑并[4,5-d]嘧啶-2-酮之對甲苯磺酸鹽等之製備中為有用的中間物。
