PHARMACEUTICAL COMPOSITION FOR TREATING AND PREVENTING DEGENERATIVE NEUROLOGICAL DISORDERS CONTAINING AS ACTIVE INGREDIENT MIXTURE EXTRACT OF MOUTAN ROOT BARK ANGELICA DAHURICA ROOT AND BUPLEURUM ROOT OR FRACTION THEREOF
KIM YOUNGMI,OH MYUNG SOOK,HONG SEON PYO,SOHN MI WON,JEONG JIN SEOK,JIANG HAI HUA,KIM EUNJIN,RYU JA YOUNG,CHO YOUNG WOONG,DU XIAO FEI,CHOI SANG ZIN,KIM JEONG SOO,KIM BYOUNG MOON
申请号：
IN201727009432
公开号：
IN201727009432A
申请日:
2017.03.17
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
Angelica dahuricain vitroThe present invention relates to a pharmaceutical composition for treating and preventing degenerative neurological disorders containing as an active ingredient a mixture extract of two or more types selected from the group consisting of moutan root bark (Moutan Radicis Cortex) root (Angelicae Dahuricae Radix) and bupleurum root (Bupleuri Radix) or a fraction thereof. Specifically the mixture extract of the present invention simultaneously exhibits a recovery effect on mitochondrial function damage a relieving effect on endoplasmic reticulum stress and an inhibitory effect on inflammatory response which are remarkably improved compared with those exhibited in an single extract and the mixture extract significantly exhibits an improvement effect on motor coordination and a protective effect on dopaminergic neurons in a Parkinson s disease animal model and thus the mixture extract of the present invention or a fraction thereof can be useful as an active ingredient of a pharmaceutical composition for treating and preventing degenerative neurological disorders.
