PHARMACEUTICAL COMPOSITION FOR TREATING AND PREVENTING DEGENERATIVE NEUROLOGICAL DISORDERS, CONTAINING, AS ACTIVE INGREDIENT, MIXTURE EXTRACT OF MOUTAN ROOT BARK, ANGELICA DAHURICA ROOT AND BUPLEURUM ROOT OR FRACTION THEREOF
University-Industry Cooperation Group of Kyung Hee University
发明人:
KIM, Youngmi,OH, Myung Sook,HONG, Seon-Pyo,SOHN, Mi Won,JEONG, Jin Seok,JIANG, Hai Hua,KIM, Eunjin,RYU, Ja Young,CHO, Young Woong,Du, Xiao Fei,CHOI, Sang Zin,KIM, Jeong Soo,KIM, Byoung Moon
申请号：
EP15842648
公开号：
EP3199171A4
申请日:
2015.09.16
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
The present invention relates to a pharmaceutical composition for treating and preventing degenerative neurological disorders, containing, as an active ingredient, a mixture extract of two or more types selected from the group consisting of Moutan Root Bark, Angelica Dahurica Root, and Bupleurum Root, or a fraction thereof. Specifically, the extract of the mixture of the present invention exhibits a recovery effect on mitochondrial function damage, a relieving effect on endoplasmic reticulum stress and also exhibits simultaneously an inhibitory effect on inflammatory response, which are remarkably improved compared with those exhibited in an in vitro single extract, and the extract of the mixture significantly exhibits an improvement effect on motor coordination and a protective effect on dopaminergic neurons in a Parkinsons disease animal model, and thus the extract of the mixture of the present invention or a fraction thereof can be useful as an active ingredient of a pharmaceutical composition for treating and preventing degenerative neurological disorders.
