Isolated binding proteins, e.g., antibodies or antigen binding portions thereof, which bind to tumor necrosis factor-alpha (TNF-α), e.g., human TNF-α, and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.本發明揭示結合腫瘤壞死因子-α(TNF-α)(例如人類TNF-α)之分離結合蛋白(例如抗體或其抗原結合部分),及基於相關抗體之組合物及分子。本發明亦揭示包含該等抗體之醫藥組合物,以及使用該等抗體之治療及診斷方法。