METHODE DE TRAITEMENT ET DOSAGE BIOLOGIQUE FAISANT APPEL A UN FACTEUR D'INHIBITION DE LA MIGRATION DES MACROPHAGES (MIF) UTILISE COMME FACTEUR DEPRESSEUR DU MYOCARDE D'ORIGINE CARDIAQUE
BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM;CYTOKINE PHARMASCIENCES, INC.
发明人:
GIROIR, BRETT,WILLIS, MONTE,DE LA CRUZ, VIDAL,SIELECKI, THAIS
申请号：
CA2537928
公开号：
CA2537928C
申请日:
2004.08.30
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
One embodiment of the present invention relates to a pharmaceuticalcomposition, which includes a therapeutically effective amount of at least oneanti-MIF antibody； and at least one pharmaceutically acceptable carrier.Another embodiment of the present invention relates to a pharmaceuticalcomposition, which includes a therapeutically effective amount at least oneanti-CD74 antibody； and at least one pharmaceutically acceptable carrier.Another embodiment of the present invention relates to a pharmaceuticalcomposition, which includes a therapeutically effective amount of at least oneanti-TNFR antibody； a therapeutically effective amount of at least one anti-MIF antibody； and at least one pharmaceutically acceptable carrier. Otherembodiments of the present invention relate to methods of treating orpreventing cardiac dysfunction, cardiodepression, burn injury-associatedcardiac dysfunction, improving cardiac function in a subject following acutemyocardial infarction, and identifying an MIF inhibitor.
