Antibodies to tropomysin receptor kinase (TrkA), compositions including such antibodies, and methods of using such antibodies for the treatment of pain including post-surgical pain, rheumatoid arthritis pain, neuropathic pain and osteoarthritis pain.本發明提供原肌球蛋白(tropomysin)受體激酶(TrkA)之抗體、包括此類抗體之組合物及使用此類抗體來治療疼痛之方法,該疼痛包括手術後疼痛、類風濕性關節炎疼痛、神經性疼痛及骨關節炎疼痛。