Drug delivery device and methods are provided for transdermal drug delivery through a skin. The device includes a gas source (18) comprising a gas or capable of selectively producing a gas. The device also includes a first collimator (40) fluidly connected with the gas source (18) adapted to form a first plurality of collimated gas streams comprising the gas. The first collimator (40) has an inlet end (44) and an outlet end (46). The device further includes a first drug source comprising a drug. The first drug source is configured to release the drug into the first plurality of collimated gas streams between the inlet end and outlet end of the first collimator.
