David Peter Cormode,Andrew Maidment,Pratap Chandra Naha,Roshan Karunamuni
申请号：
US15752308
公开号：
US20180236106A1
申请日:
2016.08.12
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Nanoparticles and nanoprobes for use as a contrast agent for X-ray imaging techniques, CT scanning techniques, MRI and optical imaging are disclosed. The nanoparticles and nanoprobes include a core having a contrast element characterized by a K-edge value ranging from about 17 to about 49 keV, and a stabilizing element which minimizes one or both of cytotoxicity and immunoreactivity of the contrast element. A first coating layer encapsulates the core, the first coating layer configured to render the nanoparticles soluble in a biological medium. A method for dual energy x-ray imaging includes the steps of administering to a subject the nanoparticles disclosed herein as a contrast agent acquiring an image with a low energy spectrum and acquiring an image with a high energy spectrum.
