An X-ray image diagnosis apparatus includes an imaging unit that supports an X-ray generation unit and an X-ray detection unit in such a way that the units face each other and is possible to take an image of a subject placed on a top panel of a bed; a control unit that performs control in such a way that a step movement process of at least one of the imaging unit and top panel is carried out and images of the subject are taken at a plurality of stages; and an image processing unit that processes image data taken at a plurality of the stages. The control unit sets a plurality of regions of interest in an imaging area of the subject when an image is taken after a contrast medium is injected into the subject, measures a change of an image level in the region of interest to detect a flow of the contrast medium, and makes at least one of the imaging unit and top panel move to the next imaging stage based on the detection result.