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NEW Pyrrole Inhibitors of S-Nitrozoglutathione Reductase as Therapeutic Agents
专利权人:
Н30 Фармасьютиклз; ЛЛК (US)
发明人:
УОСЛИ Айан (US),РОЗЕНТАЛ Гэри Дж. (US),СУНЬ Сичэн (US),СТРОНГ Сара (US),ЦЮ Цзянь (US)
申请号:
RU2011109339/04
公开号:
RU2011109339A
申请日:
2009.08.14
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. The compound of formula I or its pharmaceutically acceptable salts:! ! where Ar is selected from the group consisting of phenyl and thiophenyl; ! R1 is selected from the group consisting of unsubstituted imidazolyl, substituted imidazolyl, chloro, bromo, fluoro, hydroxy and methoxy; ! R2 is selected from the group consisting of hydrogen, methyl, chloro, fluoro, hydroxy, methoxy, ethoxy, propoxy, carbamoyl, dimethylamino, amino, formamido and trifluoromethyl; and! X is selected from the group consisting of CO and SO2. ! 2. The compound according to claim 1, where R1 is selected from the group consisting of unsubstituted imidazolyl and substituted imidazolyl. ! 3. The compound of claim 2, wherein the substituted imidazolyl group is substituted with C1-C6 alkyl. ! 4. The compound according to claim 2, where ArR1R2 is selected from the group consisting of:! ; ; ; ! ; ! where R3 is selected from H, methyl and ethyl. ! 5. The compound according to claim 2, selected from the group consisting of the following compounds:! 3- (5- (4- (1H-imidazol-1-yl) phenyl) -1- (4-carbamoyl-2-methylphenyl) -1H-pyrrol-2-yl) propanoic acid; ! 3- (5- (5- (1H-imidazol-1-yl) thiophen-2-yl) -1- (4-carbamoyl-2-methylphenyl) -1H-pyrrol-2-yl) propanoic acid; ! 3- (1- (4-carbamoyl-2-methylphenyl) -5- (4- (2-methyl-1H-imidazol-1-yl) phenyl) -1H-pyrrol-2-yl) propanoic acid; ! 3- (1- (4-carbamoyl-2-methylphenyl) -5- (4- (4-methyl-1H-imidazol-1-yl) phenyl) -1H-pyrrol-2-yl) propanoic acid; ! 3- (1- (4-carbamoyl-2-methylphenyl) -5- (4- (2-ethyl-1H-imidazol-1-yl) phenyl) -1H-pyrrol-2-yl) propanoic acid; ! 3- (5- (4- (1H-imidazol-1-yl) thiophen-2-yl) -1- (4-carbamoyl-2-methylphenyl) -1H-pyrrol-2-yl) propanoic acid; ! 3- (1- (4-carbamoyl-2-methylphenyl) -5- (5- (2-methyl-1H-imidazol-1-yl) thiophen-2-yl) -1H-pyrrole-2-yl) propanoic acid ; ! 3- (1- (4-carbamoyl-2-methylphenyl) -5- (3-fluoro-4- (1H-imidazol-1-yl) phenyl) -1H-pyrrol-2-yl) propanoic acid; ! 3- (1. Соединение формулы I или его фармацевтически п
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