Providence Health & Services - Oregon d/b/a Providence Portland Medical Center
发明人:
Redmond, William,Weinberg, Andy
申请号：
AU2012371610
公开号：
AU2012371610A1
申请日:
2012.03.02
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
OX40 is a potent immune stimulating target. Provided herein is a method of treating cancer, which includes administering to a subject in need of treatment an OX40 agonist and a common gamma chain (yc) cytokine or an active fragment, variant, analog, or derivative thereof In certain aspects the common gamma chain (yc) cytokine is interleukin-2 (IL-2) or an active fragment, variant, analog, or derivative thereof. Combined treatment with an agonist anti-OX40 mAb and IL-2 synergized to augment tumor immunotherapy against multiple tumor types. Dual therapy was also able to restore the function of anergic tumor-reactive CD8
