ADMINISTRATION D'INHIBITEUR D'ENZYME D'ACTIVATION DE LA NEDD8 ET D'AGENTS CHIMIOTHERAPEUTIQUES

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专利权人:

INC.;MILLENNIUM PHARMACEUTICALS

发明人:

BERGER, ALLISON,LIGHTCAP, ERIC S.

申请号：

CA2923752

公开号：

CA2923752A1

申请日:

2014.05.13

申请国别(地区):

CA

年份:

2014

代理人:

摘要：

Disclosed are methods for the treatment of various solid tumors in patients in need of such treatment. The methods comprise administering to such a patient an NEDD8-activating enzyme (NAE) inhibitor such as (lS,2S,4R)-4-4-(lS)-2,3-dihydro1H-inden-l-ylamino)-7H-pyrrolo[2,3-d]-pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate (MLN4924) or a pharmaceutically acceptable salt in combination with one or more chemotherapeutic agents. Also disclosed are medicaments for use in the treatment of various solid tumors.

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