ADMINISTRATION D'INHIBITEUR D'ENZYME D'ACTIVATION DE LA NEDD8 ET D'AGENTS CHIMIOTHÉRAPEUTIQUES

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专利权人:

Millennium Pharmaceuticals; Inc.

发明人:

申请号：

EP14797156.8

公开号：

EP2996773A4

申请日:

2014.05.13

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

Disclosed are methods for the treatment of various solid tumors in patients in need of such treatment. The methods comprise administering to such a patient an NEDD8-activating enzyme (NAE) inhibitor such as (1S,2S,4R)-4-4-(1S)-2,3-dihydro 1H-inden-1-ylamino)-7H-pyrrolo[2,3-d]-pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate (MLN4924) or a pharmaceutically acceptable salt in combination with one or more chemotherapeutic agents. Also disclosed are medicaments for use in the treatment of various solid tumors.

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