The United States of America; as represented by The Secretary; Department of Health and Human Services
发明人:
MORGAN Richard A.,ROSENBERG Steven A.
申请号：
SI201231451
公开号：
SI2694549T1
申请日:
2012.03.21
申请国别(地区):
SI
年份:
2018
代理人:
摘要：
The invention provides chimeric antigen receptors (CARs) comprising an antigen binding domain of human antibody 139, an extracellular hinge domain, a transmembrane domain, and an intracellular domain T cell receptor signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are also disclosed.
