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Heterocyclic carboxylic acid derivatives having 2,5-substituted oxazolopyrimidine rings
专利权人:
サノフイ
发明人:
ディーター・カーデライト,マティーアス・シェーファー,シュテファニ・ハックテル,アクセル・ディートリヒ,トーマス・フープシュリ,カトリン・ヒス
申请号:
JP2012548411
公开号:
JP5841068B2
申请日:
2011.01.12
申请国别(地区):
JP
年份:
2016
代理人:
摘要:
Heterocyclic carboxylic acid derivatives comprising a 2,5-substituted oxazolopyrimidine ring as Edg-1 receptor agonists The present invention relates to oxazolopyrimidine compounds of the formula I, in which A, R1, R2, R3, X and Y are defined as indicated in the claims. The compounds of the formula I modulate the activity of the Edg-1 receptor and in particular are agonists of this receptor, and are useful for the treatment of diseases such as atherosclerosis, heart failure or peripheral arterial occlusive disease, for example. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.
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