Use of anti-NR10 monoclonal antibody with neutralizing activity against NR10 in the manufacture of prophylactic or therapeutic agents for pruritus

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专利权人:

CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人:

HIGUCHI YOSHINOBU,KASUTANI, KEIKO,KITAMURA, HIDETOMO,HASEGAWA, MASAKAZU

申请号：

TW97147375

公开号：

TWI441649B

申请日:

2008.12.05

申请国别(地区):

TW

年份:

2014

代理人:

摘要：

The present inventors isolated clone BM095 from a human antibody phage library, which had a strong growth inhibitory activity in the IL-31-dependent Ba/F3 cell growth assay system. When administered to pruritus model mice, the anti-mouse NR10 neutralizing antibody exhibited a marked symptom-suppressing effect. Thus, it was revealed that anti-NR10 neutralizing antibodies are useful as therapeutic agents for pruritus.

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中国工程科技知识中心

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