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OSMOTIC DELIVERY DEVICE COMPRISING AN INSULINOTROPIC PEPTIDE AND USES THEREOF
专利权人:
Intarcia Therapeutics; Inc.
发明人:
Thomas R. Alessi,Ryan D. Mercer,Catherine M. Rohloff,Bing Yang
申请号:
US15291523
公开号:
US20170072022A1
申请日:
2016.10.12
申请国别(地区):
US
年份:
2017
代理人:
摘要:
A suspension formulation of an insulinotropic peptide (e.g., glucagon-like peptide-1 (GLP-1) or exenatide) is described. The suspension formulation comprises (i) a non-aqueous, single-phase vehicle, comprising one or more polymer and one or more one solvent, wherein the vehicle exhibits viscous fluid characteristics, and (ii) a particle formulation comprising the insulinotropic peptide, wherein the peptide is dispersed in the vehicle. The particle formulation further includes a stabilizing component comprising one or more stabilizers, for example, carbohydrates, antioxidants, amino acids, and buffers. Devices for delivering the suspension formulations and methods of use are also described.
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