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מערכת הובלה אוסמוטית הכוללת פורמולציות תרחיף של פפטידים אינסולינוטרופים ושימושים בהן
专利权人:
INTARCIA THERAPEUTICS INC.
发明人:
申请号:
IL20117509
公开号:
IL201175A
申请日:
2009.09.24
申请国别(地区):
IL
年份:
2014
代理人:
摘要:
A suspension formulation of an insulinotropic peptide (e.g., glucagon-like peptide-1 (GLP-1) or exenatide) is described. The suspension formulation comprises (i) a non-aqueous, single-phase vehicle, comprising one or more polymer and one or more one solvent, wherein the vehicle exhibits viscous fluid characteristics, and (ii) a particle formulation comprising the insulinotropic peptide, wherein the peptide is dispersed in the vehicle. The particle formulation further includes a stabilizing component comprising one or more stabilizers, for example, carbohydrates, antioxidants, amino acids, and buffers. Devices for delivering the suspension formulations and methods of use are also described.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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