AURIGENE DISCOVERY TECHNOLOGIES LTD.;DEBIOPHARM SA
发明人:
MC ALLISTER, ANDRES,SHETTY, SHANKAR JAYARAM,SENGUPTA, SAUMITRA,MURONE, MAXIMILIEN
申请号：
NZ60227111
公开号：
NZ602271A
申请日:
2011.02.17
申请国别(地区):
NZ
年份:
2013
代理人:
摘要：
ABSTRACT - 602271 The disclosure relates to substituted aromatic bicyclic compounds containing pyrimidine and pyridine rings of formula (I) having the structure as well as pharmaceutically acceptable salts thereof. These compounds are useful as tyrosine kinase inhibitors, preferably SRC family kinases (SFKs) inhibitors, in particular as multi SFK/JAK. kinases inhibitors and even preferably as dual c-SRC/JAK kinases inhibitors, thereby inhibiting the transcription factor signal transducer and activator of transcription 3 (STAT3) activation and therefore abnormal growth of particular cell types. Notably, these compounds are useful for the treatment or inhibition of certain diseases that are the result of deregulation of STAT3.
