Saumitra Sengupta;Andrès Mc Allister;Maximilien Murone;Shankar Jayaram Shetty
发明人:
Andrès Mc Allister,Maximilien Murone,Saumitra Sengupta,Shankar Jayaram Shetty
申请号：
US13578656
公开号：
US20130012518A1
申请日:
2011.02.17
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to substituted aromatic bicyclic compounds containing pyrimidine and pyridine rings of formula (I) having the structure as well as pharmaceutically acceptable salts thereof. The compounds of the present invention are useful as tyrosine kinase inhibitors, preferably SRC family kinases (SFKs) inhibitors, in particular as multi SFK/JAK. kinases inhibitors and even preferably as dual c-SRC/JAK kinases inhibitors, thereby inhibiting the STAT3 activation and therefore abnormal growth of particular cell types. Notably, the compounds of the present invention are useful for the treatment or inhibition of certain diseases that are the result of deregulation of STAT3.
