A compound of Formula I: ** Formula ** or an enantiomer, a mixture of enantiomers, a mixture of two or more diastereomers, a tautomer, or a mixture of two or more tautomers thereof； or a pharmaceutically acceptable salt, solvate or hydrate thereof； where: R1, R2, R3, R4, R5 and R8 are each independently (a) hydrogen, deuterium, halo, cyano, nitro or guanidine； (b) C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl, C 6-14 aryl, heteroaryl, heterocyclyl or C 7-15 aralkyl； or (c) - C (O) R1a, -C (O) OR1a, -C (O) NR1bR1c, - C (NR1a) NR1bR1c, -OR1a, -OC (O) R1a, -OC (O) OR1a, - OC (O) NR1bR1c, - OC (>； = NR1a) NR1bR1c, -OS (O) R1a, -OS (O) 2R1a, -OS (O) NR1bR1c, -OS (O) 2NR1bR1c, -NR1bR1c, -NR1aC (O ) R1d, - NR1aC (O) OR1d, -NR1aC (O) NR1bR1c, -NR1aC (>； = NR1d) NR1bR1c, -NR1aS (O) R1d, - NR1aS (O) 2R1d, -NR1aS (O) NR1bR1c, - NR1bR1c, - NR1bR1c, - NR1bR1c, - NR1bR1c (-) O) 2NR1bR1c, -SR1a, -S (O) R1a, -S (O) 2R1a, - S (O) NR1bR1c or -S (O) 2NR1bR1c R6, R7 and R9 are each deuterium； R10 and R11 are each independently (a) hydrogen； or (b) C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl, C 6-14 aryl, heteroaryl, heterocyclyl or C 7-15 aralkyl； or R10 and R11 are linked together to form a heterocyclyl； R12 is (a) hydrogen； (b) C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl, C 6-14 aryl, heteroaryl, heterocyclyl or C 7-15 aralkyl； or (c) -C (O) R1a, -C (O) OR1a, -C (O) NR1bR1c, - C (NR1a) NR1bR1c, -S (O) R1a, -S (O) 2R1a, -S (O ) NR1bR1c or -S (O) 2NR1bR1c； L is C1-6 alkylene； X is O or S； and each of R1a, R1b, R1c and R1d is independently hydrogen, deuterium, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, heteroaryl, heterocyclyl or C6-14 aryl； or each pair of R1b and R1c together with the N atom to which it is attached independently form a heteroaryl or heterocyclyl； where each alkyl, alkylene, alkenyl, alkynyl, cycloalkyl, aryl, aralkyl, heterocyclyl and heteroaryl in R1, R2, R3, R4, R5, R8, R10, R11, R12, R1a, R1b, R1c, R1d
