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Remodeling and glycopegylation of fibroblast growth factor (FGF)
专利权人:
Shawn DeFrees
发明人:
Shawn DeFrees
申请号:
US13332708
公开号:
US09200049B2
申请日:
2011.12.21
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The present invention relates to mutants of Fibroblast Growth Factor (FGF), particularly FGF-20 and FGF-21, which contain newly introduced N-linked or O-linked glycosylation site(s). The polynucleotide coding sequences for the mutants, expression cassettes comprising the coding sequences, cells expressing the mutants, and methods for producing the mutants are also disclosed. Further disclosed are pharmaceutical compositions comprising the mutants and method for using the mutants.
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