592566 Disclosed are 3-phenyl-3-methoxy-pyrrolidine derivative of Formula 1 where the substituents are as disclosed in the specification. Examples of compounds of formula (I) are: (+)-3-(3-Chloro-2-fluorophenyl)-3-methoxypyrrolidine； (+)-3-(3-Chloro-2-fluorophenyl)-1-ethyl-3-methoxypyrrolidine 3-(3,4-Difluorophenyl)-(1-D)-3-methoxypyrrolidin Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and the use of compounds of formula (I) in the manufacture of medicaments for the treatment, prevention or alleviation of a disease or a disorder or a condition of a mammal, including a human, which disease, disorder or condition is responsive to modulation of catecholamines in the cerebral cortex.
