Mezher Hussein ALI,Daniel Christopher BROOKINGS,Julien Alistair BROWN,Martin Clive HUTCHINGS,Victoria Elizabeth JACKSON,Boris KROEPLIEN,John Robert PORTER,Joanna Rachel QUINCEY
申请号：
US15038733
公开号：
US20160376275A1
申请日:
2014.12.08
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A series of substituted imidazo[1,2-b]pyridazine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders； neurological and neurodegenerative disorders； pain and nociceptive disorders； cardiovascular disorders； metabolic disorders； ocular disorders； and oncological disorders.
