A thrombectomy device (100). A thrombus aspiration system (1) and a thrombus fragmentation system (3) can be driven simultaneously by means of a manual operating assembly (1000). Before thrombus extraction, the thrombus is already cut into small thrombi by means of the thrombus fragmentation system (3), avoiding the defect in the prior art of massive thrombi blocking the lumen, which affects the efficiency of thrombus removal, and improving the surgical success rate. On the other hand, the manual operating assembly (1000) makes it possible to intuitively sense the aspiration pressure inside the blood vessel and, on the basis of the change in aspiration pressure, it is possible to intuitively perceive whether the thrombus is aspirated, the process of thrombus removal and abnormal conditions, avoiding the defect in the prior art that a surgeon cannot accurately determine the surgical process when using electric-powered aspiration, and improving the surgical accuracy.
