Refers to a process for preparing a Pharmaceutical composition comprising: (a) combining Dry at least one active substance and optionally one or more excipients such as Surfactants, binders, among others, where the active substance is a compound of formula (i) where ra is to Lifatico (C1 - C3), fluoroalifatico (C1 - C3), among others RB IS F, CH3, CF3, Oh,Among others being a Preferred Compound {[4 - (7 - 9 - chlorine - 2-fluoro-6 - (4-methoxyphenyl) 5h - 5.4 - pirimido [d] [2] benzazepin] amino} - 2 (IL - 2 - metoxibenzoato granular sodium (b) the active substance and one wet or more excipients in the presence of a Solvent such as water,Ethanol or acetone c) Drying The Wet mix to form Dry Granules (d) to Grind The Dry Granules to form Granules dispersed Granules e) combine the ground with a buffer such as sodium bicarbonate, phosphate, monosodium, among others.And optionally with one or more excipients (f) to add a LUBRICANT to the Compression and the formation of a Tablet which also covers entericamente, or load the resulting mixture from step (e) in a Capsule.It also relates to the pharmaceutical composition which contains: (i) from 1 to 60% w \/ W of the active principle (ii) from 10 to 80% w \/ W of sodium bicarbonate (iii) from 10 to 80% w \/ W of microcrystalline Cellulose (iv) from 0 to 5% W \/ W Sodium Stearyl fumarate (V) from 0 to 5% w \/ W of Sodium lauryl sulfate (VI) 0 to 20% w \/ W of polyvinylpyrrolidone and (vii) from 0 to 20% w \/ W of croscarmellose sodiumSE REFIERE A UN PROCEDIMIENTO PARA PREPARAR UNA COMPOSICION FARMACEUTICA QUE COMPRENDE: A) COMBINAR EN SECO AL MENOS UN PRINCIPIO ACTIVO Y OPCIONALMENTE UNO O MAS EXCIPIENTES TAL COMO TENSIOACTIVOS, AGLUTINANTES, ENTRE OTROS, EN DONDE EL PRINCIPIO ACTIVO ES UN COMPUESTO DE FORMULA (I) DONDE Ra ES ALIFATICO(C1-C3), FLUOROALIFATICO(C1-C3), ENTRE OTROS Rb ES F, CH3, CF3, OH, ENTRE OTROS SIENDO UN COMPUESTO PREFERIDO EL 4-{[9-CLORO-7-(2-FLUORO-6-METOXIFENIL)-5H-PIRIMIDO[5,4-d][2]BENZAZEPIN-2-IL]AMINO
