PROBLEM TO BE SOLVED: To provide agents and foods and drinks having preadipocyte differentiation induction promoting activities and effective against diabetes and insulin resistance.SOLUTION: The present invention provides preadipocyte differentiation induction promoters, agents for preventing or improving diabetes, or agents for preventing or improving insulin resistance, comprising aculeatin, aculeatin analogs or wild orange tree extracts as an active ingredient.SELECTED DRAWING: NoneCOPYRIGHT: (C)2016,JPO&INPIT【課題】前駆脂肪細胞分化誘導促進活性作用を有し、糖尿病及びインスリン抵抗性に有用な薬剤や飲食物の提供。【解決手段】アクレアチン(aculeatin)、アクレアチン類縁体またはサルカケミカンの抽出物を有効成分として含有する、前駆脂肪細胞分化誘導促進剤、糖尿病の予防または改善剤、あるいは、インスリン抵抗性の予防または改善剤。【選択図】なし